Dianna M Milewicz Selected Research

Phosphotransferases (Kinase)

1/2022	Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation.
1/2019	MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants.
1/2018	Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype.
1/2017	Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.
8/2013	Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.

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Dianna M Milewicz Research Topics

Disease

36	Thoracic Aortic Aneurysm 01/2023 - 07/2003
23	Aortic Diseases 11/2023 - 05/2009
22	Aneurysm (Aneurysms) 01/2022 - 11/2005
15	Aortic Dissection 03/2022 - 11/2010
15	Marfan Syndrome (Marfan's Syndrome) 01/2019 - 04/2003
11	Familial Thoracic 1 Aortic Aneurysm 02/2014 - 07/2005
8	Vascular Diseases (Vascular Disease) 02/2023 - 08/2006
8	Inflammation (Inflammations) 01/2022 - 10/2007
7	Aortic Aneurysm (Aneurysm, Aortic) 01/2020 - 05/2009
5	Stroke (Strokes) 10/2023 - 05/2009
5	Intracranial Aneurysm (Cerebral Aneurysm) 12/2016 - 07/2005
5	Genetic Predisposition to Disease (Genetic Predisposition) 09/2011 - 08/2003
4	Atherosclerotic Plaque (Atheroma) 11/2023 - 01/2021
4	Thoracic Aorta Dissection 01/2018 - 01/2013
3	Coronary Artery Disease (Coronary Atherosclerosis) 11/2023 - 05/2009
3	Atherosclerosis 11/2023 - 12/2020
3	Acute Aortic Syndrome 11/2023 - 12/2022
3	Moyamoya Disease (Moya-Moya Disease) 10/2023 - 05/2009
3	Loeys-Dietz Syndrome 01/2022 - 08/2006
3	Vascular Remodeling 12/2020 - 09/2006
3	Rupture 01/2020 - 01/2014
3	Type IV Ehlers-Danlos Syndrome 11/2019 - 08/2006
3	Vascular System Injuries 01/2019 - 05/2012
3	Hyperplasia 01/2019 - 08/2013
3	Patent Ductus Arteriosus 10/2018 - 11/2006
3	Hypertension (High Blood Pressure) 10/2018 - 07/2005
3	Abdominal Aortic Aneurysm 10/2017 - 09/2011
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2020 - 11/2017
2	Fibrosis (Cirrhosis) 01/2019 - 01/2005
2	Neointima 01/2019 - 05/2010
2	Bicuspid Aortic Valve Disease 01/2018 - 01/2017
2	Hypertelorism 12/2016 - 08/2006
2	Inborn Genetic Diseases (Disease, Hereditary) 09/2012 - 05/2010
1	Channelopathies 02/2024
1	Type II Microcephalic Osteodysplastic Primordial Dwarfism 11/2023
1	Hypercholesterolemia 01/2023
1	Disease Progression 01/2021
1	Bites and Stings (Sting) 01/2020
1	Ventricular Tachycardia 01/2020
1	Intestinal Perforation 01/2019
1	Spontaneous Rupture 01/2019

Drug/Important Bio-Agent (IBA)

23	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 01/2023 - 07/2003
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2012
7	Contractile ProteinsIBA 01/2023 - 11/2006
7	Transforming Growth Factor-beta Type II ReceptorIBA 01/2022 - 07/2005
7	Angiotensin IIIBA 01/2020 - 10/2007
5	CollagenIBA 02/2024 - 09/2006
5	CholesterolIBA 11/2023 - 01/2020
5	Phosphotransferases (Kinase)IBA 01/2022 - 08/2013
5	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 07/2005
5	ElastinIBA 01/2019 - 09/2006
5	Protein Isoforms (Isoforms)IBA 01/2018 - 11/2010
5	Fibrillin-1IBA 01/2017 - 04/2003
4	LipidsIBA 11/2023 - 01/2019
4	Arginine (L-Arginine)FDA Link 10/2023 - 07/2005
4	Transforming Growth Factor-beta Type I ReceptorIBA 01/2022 - 08/2006
4	Losartan (Cozaar)FDA LinkGeneric 01/2019 - 09/2013
4	Myosin-Light-Chain KinaseIBA 01/2019 - 11/2010
4	Myosin Heavy Chains (Myosin Heavy Chain)IBA 01/2018 - 11/2006
4	Myosins (Myosin)IBA 01/2018 - 12/2010
4	Transforming Growth Factor beta (TGF-beta)IBA 01/2017 - 01/2005
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2021
3	Protein Kinases (Protein Kinase)IBA 01/2022 - 01/2017
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2020 - 09/2006
3	Collagen Type III (Type III Collagen)IBA 11/2019 - 08/2006
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2021
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 01/2019
2	InflammasomesIBA 01/2020 - 01/2017
2	Hormones (Hormone)IBA 12/2017 - 04/2016
2	ThrombospondinsIBA 01/2017 - 12/2016
2	Interleukin-6 (Interleukin 6)IBA 01/2014 - 07/2013
2	Actins (F Actin)IBA 05/2009 - 12/2007
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 10/2007 - 07/2005
2	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 08/2006 - 07/2005
1	pericentrinIBA 11/2023
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 11/2023
1	Pravastatin (Pravachol)FDA LinkGeneric 01/2023
1	Chloride Channels (Chloride Channel)IBA 01/2023
1	Apolipoproteins E (ApoE)IBA 01/2023
1	Thrombospondin 1IBA 01/2022
1	ApolipoproteinsIBA 01/2022
1	Extracellular Matrix ProteinsIBA 01/2022
1	ChaperoninsIBA 12/2021
1	Chaperonin Containing TCP-1IBA 12/2021
1	oxidized low density lipoproteinIBA 12/2020
1	Scavenger Receptors (Scavenger Receptor)IBA 12/2020
1	Protein Kinase CIBA 12/2020
1	Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)IBA 12/2020
1	Oxidized LDL ReceptorsIBA 12/2020
1	N- (1,2,3,5,6,7- hexahydro- S- indacen- 4- ylcarbamoyl)- 4- (2- hydroxy- 2- propanyl)- 2- furansulfonamideIBA 01/2020
1	Mitochondrial DNA (mtDNA)IBA 01/2020
1	InterferonsIBA 01/2020
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 01/2020
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019
1	Phosphatidic Acids (Phosphatidic Acid)IBA 01/2019
1	cobinamideIBA 01/2019
1	Captopril (Capoten)FDA LinkGeneric 01/2019

Therapy/Procedure

10	Therapeutics 11/2023 - 08/2006
1	Genomic Medicine 03/2022